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Symbol
Name
ID
Ezh2
enhancer of zeste 2 polycomb repressive complex 2 subunit
MGI:107940
Phenotype annotations related to reproductive system
Darker colors indicate more annotations
Human Phenotypes
Cryptorchidism
Hydrocele testis
Uterine leiomyosarcoma
Disease(s) Associated with EZH2
colorectal cancer
Weaver syndrome

Mouse Phenotypes
decreased uterine NK cell number
impaired mammary gland growth during pregnancy
abnormal endometrial gland morphology
increased endometrial gland number
abnormal endometrium morphology
endometrium hyperplasia
enlarged uterine horn
abnormal uterine epithelium development
abnormal parturition
dystocia
reduced female fertility
decreased litter size
Availability Mouse Genotype
Gt(ROSA)26Sortm4(H1/tetO-RNAi:Ezh2)Arte/Gt(ROSA)26Sor+
Gt(ROSA)26Sortm5(H1/tetO-RNAi:Ezh2)Arte/Gt(ROSA)26Sor+
Ezh2tm2Sho/Ezh2tm2Sho
Pgrtm2(cre)Lyd/Pgr+  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory